WOUNDS AND TREATMENT


A wound is a type of injury in which skin is torn, cut or punctured (an open wound), or where blunt force trauma causes a contusion (a closed wound). In pathology, it specifically refers to a sharp injury which damages the dermis of the skin.
CLASSIFICATION OF WOUNDS
A.     OPEN
Open wounds can be classified according to the object that caused the wound. The types of open wound are:
1.      Incisions or incised wounds, caused by a clean, sharp-edged object such as a knife, a razor or a glass splinter.
2.      Lacerations, irregular tear-like wounds caused by some blunt trauma. Lacerations and incisions may appear linear (regular) or stellate (irregular). The term laceration is commonly misused in reference to incisions.
3.      Abrasions (grazes), superficial wounds in which the topmost layer of the skin (the epidermis) is scraped off. Abrasions are often caused by a sliding fall onto a rough surface.
4.      Puncture wounds, caused by an object puncturing the skin, such as a nail or needle.
5.      Penetration wounds, caused by an object such as a knife entering and coming out from the skin .
6.      Gunshot wounds, caused by a bullet or similar projectile driving into or through the body. There may be two wounds, one at the site of entry and one at the site of exit, generally referred to as a "through-and-through."
B.     CLOSED
Closed wounds have fewer categories, but are just as dangerous as open wounds. The types of closed wounds are:
1.      Contusions, more commonly known as bruises, caused by a blunt force trauma that damages tissue under the skin.
2.      Hematomas, also called a blood tumor, caused by damage to a blood vessel that in turn causes blood to collect under the skin.
3.      Crush injury, caused by a great or extreme amount of force applied over a long period of time.
TREATMENT OF WOUNDS
The overall treatment depends on the type, cause, and depth of the wound as well as whether or not other structures beyond the skin (dermis) are involved. Treatment of recent lacerations involves examining, cleaning, and closing the wound. If there is a delay in treatment and the laceration occurred more than 6-24 hours before evaluation, it may be preferable to heal by secondary intention, due to the high rate of infection associated with delayed closure. Minor wounds, like bruises, will heal on their own, with skin discoloration usually disappearing in 1–2 weeks. Abrasions, which are wounds with intact skin (non-penetration through dermis to subcutaneous fat), usually require no active treatment except keeping the area clean, initially with soap and water. Most abrasions tend to have an overall better appearance post-healing when kept moist for about a week with an ointment, such as aquaphor healing ointment or vasoline. Puncture wounds may be prone to infection depending on the depth of penetration. The entry of puncture wound is left open to allow for bacteria or debris to be removed from inside.
CLEANING WOUNDS
For simple lacerations, cleaning can be accomplished using a number of different solutions, including tap water, sterile saline solution, or an antiseptic solution, such as hydrogen peroxide. Infection rates may be lower with the use of tap water in regions where water quality is high. Evidence for the effectiveness of any cleaning of simple wound however is limited. Cleaning of a wound is also known as wound toilet.
CLOSING WOUNDS
If a person presents to a healthcare center within 6 hours of a laceration they are typically closed immediately after evaluating and cleaning the wound. After this point in time, however, there is a theoretical concern of increased risks of infection if closed immediately. Thus some healthcare providers may delay closure while others may be willing to immediately close up to 24 hours after the injury. A single study has found that using clean non sterile gloves is equivalent to using sterile gloves during wound closure.
If closure of a wound is decided upon a number of techniques can be used. These include bandages, a cyanoacrylate glue, staples, and sutures. Absorbable sutures have the benefit over non absorbable sutures of not requiring removal. They are often preferred in children. Buffering the pH of lidocaine makes the freezing less painful.
DRESSING WOUNDS
The effectiveness of dressings and creams containing silver to prevent infection or improve healing is not currently supported by evidence.
Egg Oil has been used in treating wounds and injuries. Ambroise Paré used a solution of egg yolk, oil of roses, and turpentine for war wounds, an old method that the Romans had discovered 1000 years before him. He published his first book 'The method of curing wounds caused by arquebus and firearms' in 1545.
Egg Oil is a natural emollient, and may be used externally on burn wounds, where it reduces pain and promotes re-epithilisation while minimising scars. It has been used effectively against burns in rural Ethiopia.

ANTIBIOTICS USED
Most clean open wounds do not require any antibiotics unless the wound is contaminated or the bacterial cultures are positive. Excess use of antibiotics only leads to resistance and side effects. All open wounds should be cleaned at least twice a day with warm water and soap. Once the wound is cleaned, it should be covered with moist gauze. This should be followed by application of dry gauze and then the wound covered with a bandage. The purpose of a wet to dry dressing allows the bandage to adhere to dead tissue performing a mechanical debridement when removed.This allows new healthy skin to grow and prevents debris from collecting. When the wound is clean, it may be closed with a skin graft. No wound is ever closed if it is suspected to be infected.
COMPLICATIONS
Bacterial infection of wound can impede the healing process and lead to life threatening complications. Scientists at Sheffield University have identified a way of using light to rapidly detect the presence of bacteria. They are developing a portable kit in which specially designed molecules emit a light signal when bound to bacteria. Current laboratory-based detection of bacteria can take hours or even days.
WORKUP
Individuals who have wounds that are not healing should be investigated to find the causes. Many microbiological agents can be responsible for this. The basic workup includes evaluating the wound, its extent and severity. Cultures are usually obtained both from the wound site and blood. X rays are obtained and a tetanus shot may be administered if there is any doubt about prior vaccination.


CHRONIC
Non-healing wounds of the diabetic foot are considered one of the most significant complications of diabetes, representing a major worldwide medical, social, and economic burden that greatly affects patient quality of life. Almost 24 million Americans—one in every 12—are diabetic and the disease is causing widespread disability and death at an epidemic pace, according to the Centers for Disease Control and Prevention. Of those with diabetes, 6.5 million are estimated to suffer with chronic or non-healing wounds. Associated with inadequate circulation, poorly functioning veins, and immobility, non-healing wounds occur most frequently in the elderly and in people with diabetes—populations that are sharply rising as the nation ages and chronic diseases increase.
Although diabetes can ravage the body in many ways, non-healing ulcers on the feet and lower legs are common outward manifestations of the disease. Also, diabetics often suffer from nerve damage in their feet and legs, allowing small wounds or irritations to develop without awareness. Given the abnormalities of the microvasculature and other side effects of diabetes, these wounds take a long time to heal and require a specialized treatment approach for proper healing.
As many as 25% of diabetic patients will eventually develop foot ulcers, and recurrence within five years is 70%. If not aggressively treated, these wounds can lead to amputations. It is estimated that every 30 seconds a lower limb is amputated somewhere in the world because of a diabetic wound. Amputation often triggers a downward spiral of declining quality of life, frequently leading to disability and death. In fact, only about one third of diabetic amputees will live more than five years, a survival rate equivalent to that of many cancers.
Many of these lower extremity amputations can be prevented through an interdisciplinary approach to treatment involving a variety of advanced therapies and techniques, such as debridement, hyperbaric oxygen treatment therapy, dressing selection, special shoes, and patient education. When wounds persist, a specialized approach is required for healing.
REFERENCES
1.      Fernandez R, Griffiths R (2008). Fernandez, Ritin. ed. "Water for wound cleansing". Cochrane Database Syst Rev (1): CD003861. DOI:10.1002/14651858.CD003861.pub2. PMID 18254034.
2.      Simple wound management on patient.co.uk website, viewed 2012-01-08
3.      Eliya, MC; Banda, GW (2011 Sep 7). Eliya, Martha C. ed. "Primary closure versus delayed closure for non bite traumatic wounds within 24 hours post injury". Cochrane database of systematic reviews (Online) 9: CD008574. DOI:10.1002/14651858.CD008574.pub2. PMID 21901725.
4.      Perelman, VS; Francis, GJ, Rutledge, T, Foote, J, Martino, F, Dranitsaris, G (2004 Mar). "Sterile versus nonsterile gloves for repair of uncomplicated lacerations in the emergency department: a randomized controlled trial.". Annals of Emergency Medicine 43 (3): 362–70. PMID 14985664.
5.      van den Broek, PJ (2011). "[Sterile gloves are necessary in minor surgery].". Nederlands tijdschrift voor geneeskunde 155 (18): A3341. PMID 21466736.
7.      Cepeda MS, Tzortzopoulou A, Thackrey M, Hudcova J, Arora Gandhi P, Schumann R (2010). Tzortzopoulou, Aikaterini. ed. "Adjusting the pH of lidocaine for reducing pain on injection". Cochrane Database Syst Rev 12 (12): CD006581. DOI:10.1002/14651858.CD006581.pub2. PMID 21154371.
8.      D'Amico G, Pagliaro L, Pietrosi G, Tarantino I (2010). d'Amico, Gennaro. ed. "Emergency sclerotherapy versus vasoactive drugs for bleeding oesophageal varices in cirrhotic patients". Cochrane Database Syst Rev 3 (3): CD002233. DOI:10.1002/14651858.CD002233.pub2. PMID 20238318.

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